A Study to Assess Selected Biomarkers in Subjects Requiring Daily Inhaled Corticosteroids for Persistent Asthma

Inclusion Criteria

• Inclusion Criteria:
• - Age 18 through 75 at the time of screening
• - Written informed consent and any locally required authorization obtained from the subject prior to performing any protocol-related procedures, including screening evaluations
• - History of physician-diagnosed asthma for at least 12 months prior to screening
• - Stable Medium- to high-dose ICS divided twice daily as outlined by the NHLBI Asthma Guidelines, 2007
• Exclusion Criteria:
• - Any medical condition that, in the opinion of the investigator or medical monitor, would interfere with interpretation of subject safety or study results
• - Concurrent enrollment in another clinical study
• - Use of immunosuppressive medication within 3 months prior to screening
• - Acute upper or lower respiratory infections requiring antibiotics or antiviral medications with in 30 days prior to screening or during screning period.
• - Receipt of immunoglobulin or blood products within 30 days prior to screening or during the screening period
• - Receipt of any investigational non-biological drug therapy within 30 days or 5 half-lives prior to screening whichever is longer; or receipt of any marketed or investigational biologic within 6 months or 5 half-lives prior to screening whichever is longer
• - Pregnant, lactating, or breastfeeding woman
• - Diagnosis of lung disease other than persistent asthma
• - History of smoking ≥10 pack years or any smoking within 12 months prior to
• screening
• - History of active, infectious hepatitis A, B, C or human immunodeficiency virus (HIV)