Esomeprazole for relief of upper gastrointestinal symptoms associated with continuous use of NSAIDs

Inclusion Criteria

• - Signed informed consent.
• - 18 years of age, or older.
• - Capable of completing the diary card.
• - Ability to complete the HRQL questionnaires.
• - A clinical diagnosis of a chronic condition (e.g., osteoarthritis or rheumatoid arthritis) that requires continuous daily NSAID treatment for at least 7 months. Daily NSAID treatment is defined as taking the prescribed dose for at least 5 of 7 days in any given week and can include COX-2 selective NSAIDs, multiple NSAIDs, and high-dose aspirin (>325 mg/day).
• - Daily NSAID treatment dose and type: (Must have been stable for at least 4 weeks prior to baseline endoscopy
• and; Are expected to remain stable for the duration of the study.
• and; Must be administered orally for the duration of the study. If more than one
• type of NSAID treatment is used, at least one type must be given orally.)
• - Hp negative by UBT, serology or biopsy based test, at visit 1.