An Open-label, Exploratory Trial to assess Gastric Acid Control in Critically Ill Subjects Receiving Nexium

Inclusion Criteria

• Inclusion Criteria:
• - Critically ill male or female subjects 18 years or older who have a baseline gastric aspirate pH less then or equal to 4
• - Subjects admitted to an ICU requiring mechanically ventilated
• - Subjects will have at least one additional stress ulcer risk factor
• Exclusion Criteria:
• - Anticipated use of pre-pyloric enteral feeding after screening until the end of study
• - Physician estimated survival of less then 96 hours
• - Anticipation of major surgery within 96 hours of study enrollment