An Accessorised Prefilled Syringe to an Autoinjector Pharmacokinetic Bridging Study of Tozorakimab

Study identifier:D9180C00006

ClinicalTrials.gov identifier:NCT06908577

EudraCT identifier:N/A

CTIS identifier:2024-511840-22-00

Recruiting

Official Title

A Multiple Centre, Randomised, Open-label, Parallel Group, Phase I Pharmacokinetic Comparability Study of Tozorakimab Administered using an Accessorised Prefilled Syringe (APFS) or an Autoinjector (AI) in Healthy Volunteers

Medical condition

Healthy Participants

Phase

Phase 1

Healthy volunteers

Yes

Study drug

Tozorakimab

Sex

All

Estimated Enrollment

252

Study type

Interventional

Age

18 Years - 55 Years

Date

Study Start Date: 07 Apr 2025

Estimated Primary Completion Date: 12 Nov 2025

Estimated Study Completion Date: 12 Nov 2025

Study design

Allocation: Randomized
Endpoint Classification: -
Intervention Model: Parallel Assignment
Masking: -
Primary Purpose: Treatment

Verification:

Verified 01 May 2025 by AstraZeneca

Collaborators

PAREXEL

Inclusion and exclusion criteria

Inclusion Criteria

• Healthy adults with suitable veins for cannulation or repeated venipuncture.
• All females must have a negative pregnancy test at the screening visit and on admission.
• Females of childbearing potential must not be lactating and if heterosexually active must agree to use an approved method of highly effective contraception, in order to avoid pregnancy from the time of administration of study intervention until 16 weeks after administration of the study intervention (Day 113).
• Females of non-childbearing potential must be confirmed at the screening visit.
• Sexually active fertile male participants with partners of childbearing potential must adhere to the contraception methods from the time of administration of the study intervention until 16 weeks after administration of the study intervention (Day 113).
• Have a body mass index (BMI) between 19 and 30 kg/m2 inclusive and weigh at least 55 kg and no more than 100 kg inclusive at screening and Day -1.
• Intact normal skin without potentially obscuring tattoos, scars, etc., at the injection site.

Exclusion Criteria

• History of any clinically significant disease or disorder which may either put the participant at risk because of participation in the study or influence the results of the study or the participant’s ability to participate in the study.
• Any clinically important medical/surgical procedure or trauma within 8 weeks of the screening visit, or any planned inpatient hospitalization during the study period.
• Malignancy, current or within the past 5 years, suspected malignancy or undefined neoplasms.
• Any abnormal laboratory values and vital signs.
• History of known immunodeficiency disorder, including a positive test for human immunodeficiency virus (HIV)-1 or HIV-2.
• History or treatment for hepatitis B or hepatitis C or any positive test result on screening for hepatitis B surface antigen (HBsAg), anti-hepatitis B core (HBc) antibodies, or anti-hepatitis C antibodies.
• Evidence of currently active tuberculosis (TB) disease or use of any TB drug treatment in the past 12 months or latent TB infection.
• Any clinically significant abnormalities on 12lead electrocardiogram (ECG) at the screening visit and/or admission (Day -1) to the Clinical Unit.
• History of or ongoing severe clinically important allergy/hypersensitivity, or history of hypersensitivity to monoclonal or polyclonal antibodies. History of allergy or reaction to any formulation components of the investigational medicinal product (IMP).
• Receipt of live attenuated vaccines within 30 days prior to randomization and receipt of COVID-19 or inactivated vaccines within 14 days prior to randomization.
• Has received another new chemical entity (defined as a compound which has not been approved for marketing) within 3 months or 5 half-lives of time of dosing in this study, whichever is longer.
• Receipt of any investigational biologic within 4 months or 5 half-lives prior to the date of dosing in this study, whichever is longer.

Sort by status

No locations available

Arms	Assigned Interventions
Experimental: Treatment A: Tozorakimab (Test) Participants will receive a single SC dose of tozorakimab via AI device.	Drug: Tozorakimab Tozorakimab will be administered as a single SC dose using an AI or APFS device on Day 1. Other Name: MEDI3506 Device: Autoinjector (AI) Device AI device will be used to administer single SC dose of tozorakimab on Day 1.
Active Comparator: Treatment B: Tozorakimab (Reference) Participants will receive a single SC dose of tozorakimab via APFS device with the same container closure as the AI.	Drug: Tozorakimab Tozorakimab will be administered as a single SC dose using an AI or APFS device on Day 1. Other Name: MEDI3506 Device: Accessorised Prefilled Syringe (APFS) Device APFS device will be used to administer single SC dose of tozorakimab on Day 1.

Documents available

Trial Results Summaries
Available here

Contacts

Contact

AstraZeneca Clinical Study Information Center

1-877-240-9479

[email protected]