A Study to Assess the Effect of AZD5462 on the Pharmacokinetics of Midazolam, Rosuvastatin and Digoxin

Exclusion Criteria

• - History of any clinically significant disease or disorder which may either put the participant at risk because of participation in the study, or influence the results or the participant’s ability to participate in the study including but not limited to:
• (i) Systemic sclerosis (ie, scleroderma).
• (ii) Moderate to severe valvular disease.
• (iii) Hypertrophic obstructive cardiomyopathy.
• (iv) Restrictive cardiomyopathy.
• (v) Gilbert’s syndrome.
• (vi) History of vascular or left ventricular aneurysms or prior dissections.
• (vii) Any history of joint hypermobility, Marfan’s Syndrome, or any connective tissue
• disorder.
• - History or presence of gastrointestinal, hepatic, or renal disease, or any other condition known to interfere with absorption, distribution, metabolism, or excretion of drugs.
• - Any clinically significant illness, medical/surgical procedure, or trauma within 4 weeks of the first administration of IMPs.
• - Any laboratory values with deviations at screening or admission to the study centre.
• - Any clinically significant abnormalities in clinical biochemistry, haematology, or urinalysis results.
• - Any clinically significant abnormal findings in vital signs after 5 minutes supine rest.
• - Any clinically important abnormalities in rhythm, conduction or morphology of the resting electrocardiogram (ECG) and any clinically important abnormalities in the 12-lead ECG.
• - Any positive result on screening for serum hepatitis B surface antigen, hepatitis C antibody, and human immunodeficiency virus (HIV) antibody.
• - Known or suspected history of drug abuse.
• - Has received another new chemical entity within 3 months of the first administration of IMP in this study.
• - Plasma donation within 1 month of screening or any blood donation/loss > 500 mL during the 3 months prior to screening.
• - History of severe allergy/hypersensitivity or ongoing allergy/hypersensitivity, or history of hypersensitivity to drugs with a similar chemical structure or class to AZD5462.
• - Current smokers or those who have smoked or used nicotine products within the 3 months prior to screening.
• - Positive screen for drugs of abuse or cotinine at screening or on each admission to the study centre or positive screen for alcohol on admission to the study centre prior to the first administration of the IMP.
• - Use of drugs with enzyme-inducing properties such as St John’s Wort within 3 weeks prior to the first administration of IMP.
• - Use of any prescribed or non prescribed medication including antacids, analgesics, herbal remedies, megadose vitamins and minerals during the 2 weeks or 5 half-lives of the medication, whichever is longer, prior to the first administration of IMP.
• - Known or suspected history of alcohol or drug abuse or excessive intake of alcohol.
• - Excessive intake of caffeine-containing drinks or food.
• - Involvement of any AstraZeneca, Parexel, or study centre employee or their close relatives.
• - Participants who have previously received AZD5462.
• - Participants who are vegans or have medical dietary restrictions.
• - Vulnerable participants.
• - Participants who cannot communicate reliably with the Principal Investigator (PI).
• - Clinical signs and symptoms consistent with COVID-19 by appropriate laboratory test within the last 4 weeks prior to screening or on admission.