Study identifier:D7550C00009
ClinicalTrials.gov identifier:NCT04087187
EudraCT identifier:N/A
CTIS identifier:N/A
A Randomized, 3-period, 3-treatment, Single-dose, Open-label, Single-center, Crossover Study to Assess the Pharmacokinetics of 3 Doses of AZD5718
Coronary artery disease
Phase 1
Yes
Treatment A, Treatment A, Treatment A, Treatment A, Treatment A, Treatment A, Treatment B, Treatment B, Treatment B, Treatment B, Treatment B, Treatment B, Treatment C, Treatment C, Treatment C, Treatment C, Treatment C, Treatment C
All
14
Interventional
18 Years - 55 Years
Allocation: Randomized
Endpoint Classification: -
Intervention Model: Crossover Assignment
Masking: -
Primary Purpose: Treatment
Verified 01 Apr 2020 by AstraZeneca
AstraZeneca
PAREXEL
No locations available
Arms | Assigned Interventions |
---|---|
Experimental: Arm1: AZD5718 Dose A + AZD5718 Dose B + AZD5718 Dose C Subjects will receive one tablet once daily (QD) of each treatment according to treatment arm. Treatment A: AZD5718 Dose A, Treatment B: AZD5718 Dose B, Treatment C: AZD5718 Dose C, with a minimum washout period of 4 days between each dose administration. | Drug: Treatment A Subject will be given AZD5718 Dose A tablet once daily Drug: Treatment B Subjects will be given AZD5718 Dose B tablet once daily Drug: Treatment C Subjects will be given AZD5718 Dose C tablet once daily |
Experimental: Arm2: AZD5718 Dose A + AZD5718 Dose C + AZD5718 Dose B Subjects will receive one tablet once daily (QD) of each treatment according to treatment arm. Treatment A: AZD5718 Dose A, Treatment C: AZD5718 Dose C, Treatment B: AZD5718 Dose B, with a minimum washout period of 4 days between each dose administration. | Drug: Treatment A Subject will be given AZD5718 Dose A tablet once daily Drug: Treatment B Subjects will be given AZD5718 Dose B tablet once daily Drug: Treatment C Subjects will be given AZD5718 Dose C tablet once daily |
Experimental: Arm3: AZD5718 Dose B + AZD5718 Dose A + AZD5718 Dose C Subjects will receive one tablet once daily (QD) of each treatment according to treatment arm. Treatment B: AZD5718 Dose B, Treatment A: AZD5718 Dose A, Treatment C: AZD5718 Dose C, with a minimum washout period of 4 days between each dose administration. | Drug: Treatment A Subject will be given AZD5718 Dose A tablet once daily Drug: Treatment B Subjects will be given AZD5718 Dose B tablet once daily Drug: Treatment C Subjects will be given AZD5718 Dose C tablet once daily |
Experimental: Arm4: AZD5718 Dose B + AZD5718 Dose C + AZD5718 Dose A Subjects will receive one tablet once daily (QD) of each treatment according to treatment arm. Treatment B: AZD5718 Dose B, Treatment C: AZD5718 Dose C, Treatment A: AZD5718 Dose A, with a minimum washout period of 4 days between each dose administration. | Drug: Treatment A Subject will be given AZD5718 Dose A tablet once daily Drug: Treatment B Subjects will be given AZD5718 Dose B tablet once daily Drug: Treatment C Subjects will be given AZD5718 Dose C tablet once daily |
Experimental: Arm5: AZD5718 Dose C + AZD5718 Dose A + AZD5718 Dose B Subjects will receive one tablet once daily (QD) of each treatment according to treatment arm. Treatment C: AZD5718 Dose C, Treatment A: AZD5718 Dose A, Treatment B: AZD5718 Dose B, with a minimum washout period of 4 days between each dose administration. | Drug: Treatment A Subject will be given AZD5718 Dose A tablet once daily Drug: Treatment B Subjects will be given AZD5718 Dose B tablet once daily Drug: Treatment C Subjects will be given AZD5718 Dose C tablet once daily |
Experimental: Arm6: AZD5718 Dose C + AZD5718 Dose B + AZD5718 Dose A Subjects will receive one tablet once daily (QD) of each treatment according to treatment arm. Treatment C: AZD5718 Dose C, Treatment B: AZD5718 Dose B, Treatment A: AZD5718 Dose A, with a minimum washout period of 4 days between each dose administration. | Drug: Treatment A Subject will be given AZD5718 Dose A tablet once daily Drug: Treatment B Subjects will be given AZD5718 Dose B tablet once daily Drug: Treatment C Subjects will be given AZD5718 Dose C tablet once daily |