A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase I) and Adults with End-stage Kidney Disease on Hemodialysis with a Central Venous Catheter (Phase IIa)

Study identifier:D7480C00001

ClinicalTrials.gov identifier:NCT06749457

EudraCT identifier:N/A

CTIS identifier:N/A

Recruiting

Official Title

A Phase I/IIa Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Pharmacokinetics of AZD7760 in Healthy Participants and in Patients with End-stage Kidney Disease Receiving Hemodialysis through a Central Venous Catheter

Medical condition

Staphylococcus aureus

Phase

Phase 1/2

Healthy volunteers

Yes

Study drug

AZD7760

Sex

All

Estimated Enrollment

231

Study type

Interventional

Age

18 Years - 55 Years

Date

Study Start Date: 30 Dec 2024
Estimated Primary Completion Date: 09 Oct 2026
Estimated Study Completion Date: 06 Jul 2027

Study design

Allocation: Randomized
Endpoint Classification: -
Intervention Model: Parallel Assignment
Masking: -
Primary Purpose: Prevention

Verification:

Verified 01 Jan 2025 by AstraZeneca

Sponsors

AstraZeneca

Collaborators

PAREXEL

Inclusion and exclusion criteria