A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase I) and Adults with End-stage Kidney Disease on Hemodialysis with a Central Venous Catheter (Phase IIa) - PEAK

Exclusion Criteria

• Phase I:
• - Known hypersensitivity to any component of the study intervention
• - Previous hypersensitivity, infusion-related reaction, or severe adverse reaction following administration of monoclonal antibodies (mAbs).
• - Clinically significant bleeding disorder (eg, factor deficiency, coagulopathy, or platelet disorder), or prior history of significant bleeding or bruising following intramuscular injections or venipuncture.
• - Aspartate Aminotransferase (AST) or alanine Aminotransferase (ALT) above 1.5 × upper limit of normal (ULN) at screening. Testing may be repeated once at the investigator’s discretion.
• - Estimated glomerular filtration rate < 90 mL/min/1.73 m2 calculated using the Chronic Kidney Disease Epidemiology Collaboration equation at screening.
• - Hemoglobin or platelet count below the lower limit of normal at screening. Testing may be repeated once at the investigator’s discretion.
• - White blood cell counts outside normal reference ranges unless judged by the investigator to be out of range given the known variation in white blood cell count reference interval by ethnicity. Testing may be repeated once at the investigator’s discretion.
• - History of malignancy other than treated non-melanoma skin cancers or locally treated cervical cancer in the previous 5 years.
• - Any laboratory value in the screening panel that, in the opinion of the investigator, is clinically significant or might confound analysis of study results. Testing may be repeated once at the investigator’s discretion.
• - Any clinically significant abnormalities on 12-lead electrocardiogram (ECG) at screening, as judged by the investigator.
• - Acute (time-limited) illness, including fever ≥ 38 °C (100.4 °F), one day prior to or on day of planned dosing; participants excluded for transient acute illness may be dosed if illness resolves within the 28-day Screening Period or may be rescreened once.
• - Known or suspected congenital or acquired immunodeficiency, or receipt of immunosuppressive therapy, including any course of glucocorticoid therapy exceeding 2 weeks of prednisone or equivalent at a dose of 20 mg daily or every other day within 6 months prior to screening.
• - Any condition that has the potential to increase clearance of the study intervention (eg, protein loss conditions such as severe enteropathies, or plasmapheresis).
• - Blood drawn in excess of a total of 450 milliliters (mL) (1 unit) for any reason within 2 months prior to screening.
• - Absence of suitable veins for blood sampling and administration of study intervention.
• - Any other condition that would compromise safety of the participants.
• - Any condition that, in the opinion of the investigator, might interfere with evaluation of the study intervention or interpretation of participant safety or study results.
• Phase IIa:
• - Known hypersensitivity to any component of the study intervention.
• - History of allergic disease or reactions likely to be exacerbated by any component of the study intervention as listed in dose formulation section.
• - Previous hypersensitivity, infusion-related reaction, or severe adverse reaction following administration of mAbs.
• - Hemoglobin < 9 g/dL at screening considered by the investigator to be due to acute condition(s). Testing may be repeated once at the investigator’s discretion.
• - Serum albumin of < 3 g/dL at screening considered by the investigator to be due to acute condition(s). Testing may be repeated once at the investigator’s discretion.
• - Myocardial infarction, acute coronary syndrome, stroke, seizure, or a
• thrombotic/thromboembolic event (eg, deep vein thrombosis or pulmonary embolism, but excluding vascular access thrombosis) within 90 days prior to randomization.
• - Known S aureus infection within 90 days of study entry.
• - Known acute viral or bacterial infection or symptoms/signs consistent with such an infection within the 21 days prior to infusion or study intervention. Mild intercurrent viral illness with a temperature of 38.1 °C (100.6 °F) or less does not require exclusion, if in the judgement of the investigator this illness will not interfere with the evaluation of the mAb.
• - Participants with malignancy undergoing chemotherapy.
• - Scheduled date for living donor kidney transplant.
• - Plans to switch to peritoneal dialysis within the primary endpoint time period (181 days).
• - Participants with a scheduled calendar date for transition to arteriovenous graft or arteriovenous graft in place and maturing.
• - Participants with a scheduled calendar date for transition to arteriovenous fistula, or arteriovenous fistula in place and maturing, with anticipated use of fistula within 90 days.