Study to assess MEDI4736 with either AZD9150 or AZD5069 in advanced solid tumors & relapsed metastatic Squamous cell carcinoma of head & neck - None

Study identifier:D5660C00004

ClinicalTrials.gov identifier:NCT02499328

EudraCT identifier:2015-002525-19

CTIS identifier:N/A

Recruitment Complete

Official Title

A Phase 1b/2, Open-Label, Multicentre Study Assessing the Safety, Tolerability, Pharmacokinetics, and Preliminary Anti-tumor Activity of MEDI4736 in Combination With AZD9150 or AZD5069 in Patients With Advanced Solid Malignancies and Subsequently Comparing AZD9150 and AZD5069 Both as Monotherapy and in Combination With MEDI4736 as Second Line Treatment in Patients With Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck.

Medical condition

Advanced solid tumors & Metastatic Squamous Cell Carcinoma of the Head and Neck

Phase

Phase 1/2

Healthy volunteers

Study drug

AZD9150, MEDI4736, AZD5069, tremelimumab (treme)

Sex

All

Actual Enrollment

340

Study type

Interventional

Age

18 Years - 130 Years

Date

Study Start Date: 06 Aug 2015

Primary Completion Date: 28 Feb 2020

Estimated Study Completion Date: 16 Mar 2025

Study design

Allocation: Randomized
Endpoint Classification: Safety/Efficacy
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment

Verification:

Verified 01 Mar 2024 by AstraZeneca

Collaborators

MedImmune Inc.

Inclusion and exclusion criteria

Inclusion Criteria

- Male and female patients must be at least 18 years of age.
- Has an Eastern Cooperative Oncology Group (ECOG) PS score of 0 or 1.
- Has measurable disease, defined as at least 1 lesion that can be accurately measured in at least 1 dimension (longest diameter to be recorded) with a minimum size of 10 mm by computerised tomography (CT) scan, except lymph nodes which must have minimum short axis size of 15 mm (CT scan slice thickness no greater than 5 mm in both cases). Indicator lesions must not have been previously treated with surgery, radiation therapy, or radiofrequency ablation unless there is documented progression after therapy.
-Has undergone ≤3 previous regimens (depending on treatment arm) of cytoreductive therapies including, but not limited to, platinum-based compounds, taxanes, or 5-fluorouracil. for B7 & B8, no prior systemic treatments should have been received for RM SCCHN
-Adequate organ and marrow function
-Female subjects of childbearing potential and male subjects with partners of childbearing potential should ensure use of a highly effective method of birth control as defined in study protocol
- Additional inclusion for part A: Has a histological confirmation of a solid malignancy (other than HCC) that is refractory to standard therapy or for which no standard of care regimen currently exists.
-Addition inclusion for Part A (A6) Has a histological confirmation of castrate-resistant prostate cancer
- Additional inclusion for Part B:Has histologically and/or cytologically confirmed SCCHN that is RM and not amendable to curative therapy by surgery or radiation. Squamous cell carcinoma of the head and neck originating from the following sites is eligible: oral cavity, oropharynx, larynx, or hypopharynx. Has at least 1 SCCHN tumour lesion (TL) amenable to biopsy and must have failed, refused, or has been found to be ineligible for least 1 prior platinum-based chemotherapy for RM-SCCHN
Additional inclusion criteria for Arms B1 & B2: must have had prior exposure to anti PDL-1 antibody
-Arms B1-B6: Has undergone 1-3 previous regimens of cytoreductive chemo-therapies
Arm B7 & B8: with no prior exposure to anti-PD-(L)1 therapies and have received no prior systemic treatment for RM SCCHN

Exclusion Criteria

- Spinal cord compression unless asymptomatic and not requiring steroids for at least 4 weeks before the start of study treatment. - Presently has a second malignancy other than SCCHN, or history of treatment for invasive cancer other than SCCHN in the past 3 years. Exceptions are:
Previously treated in-situ carcinoma (ie, noninvasive)
Cervical carcinoma stage 1B or less
Noninvasive basal cell and squamous cell skin carcinoma
Radically treated prostate cancer (prostatectomy or radiotherapy) with normal prostate-specific antigen, and not requiring ongoing antiandrogen hormonal therapy
- Patients must have completed any previous cancer-related treatments before enrolment. Any concurrent chemotherapy [Chemotherapy washout within 21 days or 5 half-lives (whichever is shorter) from enrolment], radiotherapy, immunotherapy, or biologic, or hormonal therapy for cancer excludes the patient (concurrent use of hormones for noncancer-related conditions [eg, insulin for diabetes and hormone replacement therapy] is acceptable),
-Experiencing CTCAE grade >1 events, experienced immune-related grade ≥3AEs with prior immunotherapy
-Has active or prior autoimmune disease within the past 2 years
-Has active or prior inflammatory bowel disease or primary immunodeficiency
-Undergone an organ transplant that requires use of immunosuppressive treatment
-Abnormalities in rhythm, conduction or morphology of resting 12-lead ECG
-uncontrolled comorbid conditions
-Received a live attenuated vaccine within 30 days of first study dose, unable to take oral medications
-History of allergic reactions to study compounds or excepients
Additional exclusion criteria Part A: Patients with clinically active brain metastases and prior exposure to AZD9150, AZD5069, MEDI4736, or any other anti PD (L)1 antibody.
Additional exclusion criteria Part B: Patients with brain metastases (known or suspected)
Additional exclusion criteria Part B: treatment arms B3, B4, B5, B6, B7 and B8: prior exposure to AZD9150, AZD5069, MEDI4736, or any other anti PD (L)1 antibody.

The dose-escalation Part A of this study will involve patients with advanced solid malignancies refractory to standard therapy or for which no standard of care regimen currently exists. Approximately 30 evaluable patients per treatment arm (A1 or A2) will be enrolled. A3 will test viability of alternate dosing schedule for AZD5069, A4/A5 will evaluate AZD9150/AZD5069 in fixed dose combination with MEDI4736 and tremelimumab in solid tumors. there may also be safety run in cohorts enrolled (A6/A7) in specific solid tumor types (breast and prostate cancer). Once the maximum tolerated doses (MTDs) for each of the 2 agents (AZD9150/AZD5069)in combination with MEDI4736 have been identified or the maximum doses of each of the 2 agents in combination with MEDI4736 have been reached, the dose expansion Part B of the study would commence. It will be conducted in patients with recurrent and/or metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN). Between 68 and 266 eligible patients will be enrolled and will randomly assigned to 1 of the following 6 treatment arms or non randomized arm B7: -Treatment arm B1: AZD9150 in combination with MEDI4736 in patients with prior exposure to anti-PD-(L)1 antibodies -Treatment arm B2: AZD5069 in combination with MEDI4736 in patients with prior exposure to anti-PD-(L)1 antibodies -Treatment arm B3: AZD9150 in combination with MEDI4736 in patients with no prior exposure to anti-PD-(L)1 antibodies (2L RM SCCHN) -Treatment arm B4: AZD5069 in combination with MEDI4736 in patients with no prior exposure to anti-PD-(L)1 antibodies -Treatment arm B5: AZD9150 alone in patients with no prior exposure to anti-PD-(L)1 antibodies -Treatment arm B6: AZD5069 alone in patients with no prior exposure to anti-PD-(L)1 antibodies -Treatment arm B7: (non randomized): AZD9150 in combination with MEDI4736 in patients with no prior exposure to anti-PD-(L)1 antibodies (1L RM SCCHN) -Treatment arm B8: (non randomized): AZD9150 (every two weeks) in combination with MEDI4736 in patients with no prior exposure to anti-PD-(L)1 antibodies (1L RM SCCHN)

No locations available

Arms	Assigned Interventions
Experimental: Part A1: AZD9150 / MEDI4736 Patients allocated in cohort of arm A1 (AZD9150/MEDI4736 will be evaluated for DLT until an MTD is achieved.	Drug: AZD9150 AZD9150 Drug: MEDI4736 MEDI4736
Experimental: Part A2: AZD5069 / MEDI4736 Patients allocated in cohort of arm A2 (AZD5069/MEDI4736 will be evaluated for DLT until an MTD is achieved.	Drug: MEDI4736 MEDI4736 Drug: AZD5069 AZD5069
Experimental: Part B1:AZD9150+MEDI4736:PDL1 pretreated Patients in arm B1 will be evaluated for efficacy until disease progression and then followed-up for safety and survival.	Drug: AZD9150 AZD9150 Drug: MEDI4736 MEDI4736
Experimental: Part B2:AZD5069+MEDI4736:PDL1 pretreated Patients in arm B2 will be evaluated for efficacy until disease progression and then followed-up for safety and survival.	Drug: MEDI4736 MEDI4736 Drug: AZD5069 AZD5069
Experimental: Part B3: AZD9150+MED4736:naiive 2L Patients in arm B3 will be evaluated for efficacy until disease progression and then followed-up for safety and survival.	Drug: AZD9150 AZD9150 Drug: MEDI4736 MEDI4736
Experimental: Part B4:AZD5069+MEDI4736:naiive patients Patients in arm B4 will be evaluated for efficacy until disease progression and then followed-up for safety and survival.	Drug: MEDI4736 MEDI4736 Drug: AZD5069 AZD5069
Experimental: Part B5: AZD9150 in naiive patients Patients in arm B5 will be evaluated for efficacy until disease progression and then allowed to receive additional MEDI4736 and followed for safety and survival	Drug: AZD9150 AZD9150
Experimental: Part B6:AZD5069 in naiive patients Patients in arm B6 will be evaluated for efficacy until disease progression and then allowed to receive additional MEDI4736 and followed for safety and survival	Drug: AZD5069 AZD5069
Experimental: Part A3: AZD5069/MEDI4736 Patients allocated in cohort of arm A3 (AZD5069/MEDI4736) will be evaluated for DLT and viability as alternate dosing option for Phase 2 studies	Drug: MEDI4736 MEDI4736 Drug: AZD5069 AZD5069
Experimental: Part A4: AZD9150/Treme/MEDI4736 Patients allocated in cohort of arm A4 (AZD9150/treme/MEDI4736) will be evaluated for DLT and MTD	Drug: AZD9150 AZD9150 Drug: MEDI4736 MEDI4736 Drug: tremelimumab (treme) tremelimumab
Experimental: Part A5: AZD5069/Treme/MEDI4736 Patients allocated in cohort of arm A5 (AZD5069/treme/MEDI4736) will be evaluated for DLT and MTD.	Drug: MEDI4736 MEDI4736 Drug: AZD5069 AZD5069 Drug: tremelimumab (treme) tremelimumab
Experimental: Part A6: AZD9150/MEDI4736 Patients allocated in cohort of arm A6 (AZD9150/MEDI4736) will be evaluated for safety, PK and PD.	Drug: AZD9150 AZD9150 Drug: MEDI4736 MEDI4736
Experimental: Part A7: AZD5069/MEDI4736 Patients allocated in cohort of arm A7 (AZD5069/MEDI4736) will be evaluated for safety, PK and PD.	Drug: MEDI4736 MEDI4736 Drug: AZD5069 AZD5069
Experimental: Part B7: AZD9150+MEDI4736: naiive 1L Patients in Arm B7 will be evaluated for efficacy until disease progression and then followed up for safety and survival	Drug: AZD9150 AZD9150 Drug: MEDI4736 MEDI4736
Experimental: Part B8: AZD9150 (every other week)+MEDI4736: naive 1L Patients in Arm B8 will be evaluated for efficacy until disease progression and then followed up for safety and survival	Drug: AZD9150 AZD9150 Drug: MEDI4736 MEDI4736

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Trial Results Summaries
Available here

Contacts

Contact

AstraZeneca Clinical Study Information Center

1-877-240-9479

[email protected]

Contact Backup

Cancer Study Locator

877 400 4656

[email protected]

Investigators

Principal Investigator

Dr David Hong

MD Anderson Cancer Center