Effect of Roflumilast at Acute Exacerbations of Chronic Obstructive Pulmonary Disease - TREAT

Inclusion Criteria

• -Written informed consent (IC)
• -Age ≥ 40 years
• -History of COPD for at least 12 months prior to enrollment (Visit V0)
• -Chronic productive cough for 3 months in each of the 2 years prior to enrollment (if other causes of productive cough have been excluded) and/or an exacerbation with predominantly bronchitic symptoms at enrollment
• -Presentation of an acute exacerbation of COPD that will be associated with increased sputum volume or change in sputum colour
• -Documented fixed airway obstruction determined by an FEV1/FVC ratio (post-bronchodilator) < 70% (if a pulmonary function test is not possible at Visit V0 a previous measurement can be taken which must not be older than 6 months)
• -Former smoker (defined as: smoking cessation at least 1 year ago) or current smoker both with a smoking history of at least 10 pack years
• Main