Single and Multiple Dose Study in Japanese

Inclusion Criteria

• - Able to understand the study procedures, the risks involved and willing to provide written Informed Consent before the first study related activity.
• - Healthy adult subjects born in Japan
• - All laboratory parameters should be within normal limits or considered not clinically significant by the investigator.
• - Screening serum uric acid level >= 4.5 mg/dL.
• - Subjects must be free of any clinically significant disease that requires a physician's care and/or would interfere with study evaluations or procedures.
• - Subject does not have clinically relevant abnormalities in blood pressure, heart rate, body temperature, and respiratory rate, as per the Investigator's judgment.