PT003 MDI Cardiovascular Safety Study

Exclusion Criteria

• •Women who are pregnant or lactating
• •Primary diagnosis of asthma
• •Alpha-1 antitrypsin deficiency as the cause of COPD
• •Active pulmonary diseases
• •Prior lung volume reduction surgery
• •Abnormal chest X-ray (or CT scan) not due to the presence of COPD
• •Hospitalized due to poorly controlled COPD within 3 months of Screening
• •Clinically significant medical conditions that preclude participation in the study (e.g. clinically significant abnormal ECG, uncontrolled hypertension, glaucoma, symptomatic prostatic hypertrophy)
• •Cancer that has not been in complete remission for at least 5 years
• •Treatment with investigational study drug or participation in another clinical trial or study within the last 30 days or 5 half lives
• •Clinically significant abnormal findings during the baseline Holter recording
• •Patients with a pacemaker or ICD/CRT/CRT_D devices
• Other inclusion/exclusion criteria as defined by the protocol