Study to Assess the Efficacy and Safety of MEDI3506 in Adults with Uncontrolled Moderate-to-severe Asthma - FRONTIER-3

Exclusion Criteria

• • Participants with a positive diagnostic nucleic acid test for SARS-CoV-2.
• • Participants with a significant COVID-19 illness within 6 months of enrolment:
• • Participants with a recent history of, or who have a positive test for, infective hepatitis or unexplained jaundice, or participants who have been treated for hepatitis B, hepatitis C, or HIV.
• • Evidence of active or latent TB:
• • An LVEF < 45% measured by echocardiogram during screening.
• • A family history of heart failure.
• • Current smokers or recent ex-smokers i.e., have quit e cigarettes or other inhaled tobacco products ≤ 6 months prior to SV1.
• • Ex-smokers with a total smoking history of > 10 pack years.
• • As judged by the investigator, any evidence of any active medical or psychiatric condition or other reason (prior to randomisation) that in the investigator’s opinion makes it undesirable for the participant to participate in the study.
• • Any clinically important pulmonary disease other than asthma.
• • Any other clinically relevant abnormal findings on physical examination or laboratory testing, that in the opinion of the investigator or medical monitor might compromise the safety of the participant in the study or interfere with evaluation of the study intervention.
• • A known history of severe reaction to any medication including biologic agents or human gamma globulin therapy.
• • History of, or a reason to believe, a participant has a history of, drug or alcohol abuse within the past 2 years.
• • Current diagnosis of cancer.
• • History of cancer, except if treated with apparent success with curative therapy (response duration of > 5 years).
• • History of allogeneic bone marrow transplant.
• • A helminth parasitic infection diagnosed within 6 months prior to SV4 (randomisation) that has not been treated, or has not responded to SOC therapy.
• • An asthma exacerbation within 8 weeks.
• • Receiving any prohibited concomitant medications or therapies as specified in the protocol:
• Known history of allergy or reaction to any component of the study intervention formulation, including hereditary fructose intolerance.