Iressa Versus Docetaxel (Taxotere)

Exclusion Criteria

• - Prior ZD1839 therapy
• - Prior docetaxel treatment for NSCLC
• - Less than 14 days since completion of prior radiotherapy
• - Less than 21 days since prior chemotherapy, immunotherapy or biological systemic anticancer therapy
• - Evidence of clinically active Interstitial Lung Disease
• - Other co-existing malignancies or malignancies diagnosed within the last 5 years with the exception of basal cell carcinoma or cervical cancer in situ
• - Newly diagnosed CNS metastases that have not yet been treated with surgery and/or radiation. Patients with previously diagnosed and treated CNS metastases or spinal cord compression may be considered if they have evidence of clinically SD (no steroid therapy or steroid dose being tapered) for at least 28 days
• - Patients with pre existing peripheral neuropathy >= grade 2 (NCI CTC criteria)