A study to assess the amount of drug levels in blood and safety of AZD5718 formulations in healthy volunteers

Exclusion Criteria

• Volunteers will not enter the study if any of the following exclusion criteria are fulfilled:
• • History of any clinically significant disease or disorder which, in the opinion of the Investigator, may either put the volunteer at risk because of participation in the study, or influence the results or the volunteer’s ability to participate in the study.
• • History or presence of gastrointestinal, hepatic or renal disease, or any other condition known to interfere with absorption, distribution, metabolism, or excretion of drugs.
• • Any clinically significant illness, medical/surgical procedure, or trauma within 4 weeks of the first dosing.
• • Any clinically significant abnormalities in hematology, clinical chemistry, or urinalysis results, at screening or on admission to the Clinical Unit (Day -1), as judged by the Investigator, including:
• a. Alanine aminotransferase (ALT) >1.5 x upper limit of normal (ULN).
• b. Aspartate aminotransferase (AST) >1.5 x ULN.
• c. Total bilirubin (TBL) >1.5 x ULN.
• d. Gamma glutamyl transpeptidase (GGT) >1.5 x ULN.
• Out-of-range test may be repeated once for each visit at the discretion of the Investigator.
• • Known or suspected Gilbert’s syndrome.
• • Any clinically significant abnormal findings in vital signs at screening or on admission to the Clinical Unit, as judged by the Investigator.
• • Any clinically significant abnormalities on 12-lead ECG at screening, as judged by the Investigator.
• • Any positive result on screening for serum hepatitis B surface antigen (HBsAg), hepatitis C antibody, and human immunodeficiency virus (HIV) antibody.
• • Known or suspected history of drug abuse, as judged by the Investigator.
• • Has received another new chemical entity (defined as a compound which has not been approved for marketing) within 3 months of first dosing in this study. The period of exclusion begins 3 months after the final dose or 1 month after the last visit whichever is the longest.
• • Plasma donation within 1 month of screening or any blood donation/loss more than 500 mL during the 3 months prior to screening.
• • History of severe allergy/hypersensitivity or ongoing allergy/hypersensitivity, as judged by the Investigator or history of hypersensitivity to drugs with a similar chemical structure or class to AZD5718.
• • Current smokers or those who have smoked or used nicotine products (including e cigarettes) within the 3 months prior to screening.
• • Excessive intake of caffeine containing drinks or food (e.g., coffee, tea, chocolate) as judged by the Investigator.
• • Positive screen for drugs of abuse or cotinine at screening or admission to the Clinical Unit or positive screen for alcohol on admission to the Clinical Unit.
• • Use of drugs with enzyme-inducing properties such as St John’s Wort within 3 weeks prior to first dosing.
• • Use of any prescribed or non prescribed medication including antacids, analgesics (other than paracetamol/acetaminophen), herbal remedies, megadose vitamins (intake of 20 to 600 times the recommended daily dose) and minerals during the 2 weeks prior to first dosing or longer if the medication has a long half-life.
• • Known or suspected history of alcohol or excessive alcohol intake, as judged by the Investigator.
• • Involvement of any AstraZeneca, Parexel or study site employee or their close relatives.
• • Volunteers who have previously received AZD5718.
• • Judgement by the Investigator that the volunteers should not participate in the study if they have any ongoing or recent (i.e., during the screening period) minor medical complaints that may interfere with the interpretation of study data or are considered unlikely to comply with study procedures, restrictions, and requirements.
• • Vulnerable volunteers, e.g., kept in detention, protected adults under guardianship, trusteeship, or committed to an institution by governmental or juridical order.