AZD1390 Administration of a Microdose [11C]AZD1390 to healthy volunteers

Exclusion Criteria

• -Known or suspected neurological or behavioural disorders or symptoms that may interfere with the conduct or interpretation of the study, dementia (significant concomitant neurological disease are included under this category).
• -Current significant major or unstable respiratory, heart, cerebrovascular, haematological, hepatic, renal, gastrointestinal diseases, or other major disease.
• -Suffers from claustrophobia that limits the ability to undergo the scanning procedure.
• -Subject has implanted metal devices or implants (MRI contraindications).
• -Subject has received any concomitant medication or herbal medicine within 2 weeks prior to study drug administration.
• -Subject has a negative Allen test in both hands at screening, unless brachial artery is used for arterial cannulation.
• -Use of any anticoagulant within 30 days prior to study drug administration.
• -Subject has previously participated in a PET imaging study.
• -Central nervous system infarct, infection or focal lesions of clinical significance on brain MRI scan or abnormalities observed on the brain MRI that would interfere with image analysis
• -As judged by the investigator, subject with unstable hypertension or symptomatic hypotension, history of pre-syncope or syncope due to orthostatic hypotension and/or induced by change of posture (orthostatic hypotension defined as 25 mmHg decrease in systolic and/or 15 mmHg).
• -Presence of significant abnormalities on physical and neurological clinical examinations, vital signs, ECG and clinical chemistry, haematology, or urine analysis results at screening that may interfere with the study or present a safety risk to the study subject.
• -History or positive results for a systemic infection (e.g. hepatitis B virus, hepatitis C virus, HIV, tuberculosis), including previous or on-going infectious or autoimmune disease at screening.
• -History of alcohol or drug abuse or dependence (except nicotine) within 1 year prior to screening and/or urine drug screen positive for drug abuse.
• -Prolonged QTcF >450 ms or family history of long QT syndrome.
• -History of severe allergy/hypersensitivity or ongoing clinically significant allergy/hypersensitivity, as judged by the investigator or history of hypersensitivity to drugs with a similar chemical structure or class to [11C]AZD1390.
• -Judgment by the investigator of any other reason that would prohibit the inclusion of the subject in the study.