Relative bioavailability study to compare inhalation of Terbutaline Sulphate 1,5mg via Turbuhaler M3 with Turbuhaler M2

Exclusion Criteria

• 1.History or presence of respiratory, gastrointestinal, hepatic or renal disease or any other
• condition known to interfere with absorption, distribution, metabolism or excretion
• of drugs (except for cholecystectomy)
• 2.Current smokers or those who have smoked or used nicotine products within the
• previous 3 months should be excluded
• 3.Plasma donation within 1 month of screening or any blood donation or blood loss of
• more than 500 mL during the 3 months prior to screening
• 4.History of severe allergy/hypersensitivity or ongoing allergy/hypersensitivity, as
• judged by the Principal Investigator or history of hypersensitivity to terbutaline (or
• drugs of a similar chemical structure or class) or inhaled lactose
• 5.Positive screen for drugs of abuse and/or alcohol and/or cotinine at screening
• (Visit 1) or on admission to the study centre (Day -1) prior to administration of the investigational medical product
• (IMP) on Day 1
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