A study to investigate the effect of administration of ceftazidime-avibactam (CAZ-AVI) and ceftaroline fosamil -avibactam (CXL) on the intestinal flora of healthy volunteers

Inclusion Criteria

• 1. Provision of signed and dated, written informed consent prior to any study specific procedures
• 2. Healthy male and female volunteers aged 18 to 45 years (inclusive) with suitable veins for cannulation or repeated venepuncture.
• Females: Female healthy volunteers are authorised to participate in this study if both of the following criteria are met:
• a) A negative serum pregnancy test BOTH at screening AND at admission to the study centre.
• b) Agrees not to attempt pregnancy while receiving investigational product and for a period of 7 days after last investigational product administration, and agrees to the use of acceptable methods of contraception (according to instructions) prior to, during, and for 7 days after the last investigational product administration.
• 3. Have a body mass index (BMI) between 19 and 30 kg/m2.