A Phase I Study to Assess the Safety, Tolerability and PK of Ceftazidime-Avibactam in Healthy Chinese Subjects

Inclusion Criteria

• - Provision of signed and dated, written informed consent prior to any study-specific procedures.
• -Healthy male and female (of non-child bearing potential) Chinese subjects, with suitable veins for cannulation or repeated venipuncture
• - BMI 19 to 24 kg/m2 inclusive and weigh at least 50 kg and no more than 100 kg.
• Key Exclusion Criteria:
• - Any clinical condition requiring the regular use of any medication.
• -Consumption of alcohol, drug, tobacco (cigarettes).
• - Sensitive to any food, or any serious reaction to carbapenem, cephalosporin, or other β-lactam antibiotics.
• - Severe medical or psychiatric condition or laboratory abnormality.
• - Blood donation.
• - 12 lead ECG abnormal.