Assessment of safety, tolerability and blood concentrations of single doses of AZD3839 in healthy volunteers

Exclusion Criteria

• - History of any clinically significant disease or disorder which, in the opinion of the Investigator, may either put the healthy volunteer at risk because of participation in the study, or influence the results or the healthy volunteer’s ability to participate in the study
• -History of psychotic disorder amongst first degree relatives
• -Significant orthostatic reaction at enrolment as judged by the Investigator
• -Prolonged QTcF greater than 450 msec or shortened QTcF less than 340 msec or family history of long QT syndrome or sudden death
• -Healthy volunteer is a vegetarian/lactose intolerant (exclusion criterion only applicable for healthy volunteers participating in Part 2