To assess the safety, tolerability and pharmacokinetics of AZD2820 after single ascending doses

Exclusion Criteria

• - History of any clinically significant disease or disorder which, in the opinion of the investigator, may either put the subject at risk because of participation in the study, or influence the results or the subject’s ability to participate in the study
• - History or presence of gastrointestinal, hepatic or renal disease or any other condition known to interfere with absorption, distribution, metabolism or excretion of drugs
• - A history of erectile dysfunction or anatomic abnormality of the penis (eg, cavernosal fibrosis, Peyronie’s disease, or plaques) which interferes with normal erectile function
• - Predisposition or history of priapism (eg, sickle cell anemia or trait).
• - Any clinically significant illness, medical/surgical procedure or trauma within 4 weeks of the first administration of investigational product