Study evaluating absorption, distribution, metabolism and excretion (ADME) of single dose [14C] selumetinib in volunteers

Exclusion Criteria

• - Current or past history of central serous retinopathy or retinal vein thrombosis, intraocular pressure greater than 21 mmHg or uncontrolled glaucoma.
• - Exposure to radiation levels above background exceeding 5 mSv in the last 12 months or 10 mSv in the last 5 years.
• - History or presence of any clinically significant disease or disorder in the opinion of the investigator
• - Any clinically important abnormalities in clinical chemistry, haematology, or urinalysis results, vital signs or ECG at baseline in the opinion of the Investigator.