Positron emission tomography (PET) study with [11C]AZ12713580 to determine central mGluR5 receptor occupancy of AZD2066 - PET

Exclusion Criteria

• - History of previous or ongoing psychiatric disease or condition including psychosis, affective disorder, anxiety disorder, borderline state and personality disorder according to the criteria in the Diagnostic and Statistical Manual of Mental Disorders
• - History of psychotic disorder among first degree relatives (parents, siblings)
• - History of use of antipsychotic, antidepressant or anxiolytic (anxiety treatment) drugs, prescribed or non-prescribed use. History of antidepressants or anxiolytics for non-psychiatric conditions such as pain or post-operative insomnia is allowed