The following trials provide information to treat various types of disease of the brain and the central and local nervous systems, both for ongoing and completed clinical trials. For more information on this therapy area please click here.
- collapse A Phase I, Single-center, Double-blind, Randomized, Placebo-controlled Study to Assess the Safety, Tolerability, and Pharmacokinetics of AZD7268 When Given in Multiple Ascending Oral Doses in Healthy Subjects
- collapse A Phase IIa, Multi-center, Randomized, Double-bind, Double-dummy, Active and Placebo Controlled, Parallel Group Study to Assess the Efficacy and Safety of AZD7268 in patients with Major Depressive Disorder
- collapse A phase I open-labeled, fixed sequence study to determine the effect of multiple doses of AZD6280 on the pharmacokinetics of midazolam (CYP3A4) and caffeine (CYP1A2)
- collapse A phase 1, single centre, single dose, double-blind, double-dummy, four-way crossover, placebo-controlled, randomized study to investigate the effects of AZD6280 on sedation, cognition and EEG in comparison with lorazepam in healthy male volunteers
- collapse An open label positron emission tomography (PET) study with (11C)flumazenil to determine central GABAA receptor occupancy of AZD6280 after oral administration to healthy volunteers.
- collapse A Phase I, Single-Center, Randomized, Double-Blind, Placebo-Controlled, Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD6280 When Given in Multiple Ascending Oral Doses in Healthy Male and Healthy Female Subjects of Non-child Bearing Potential.
- collapse A Phase I, Single-center, Randomized, Double-blind, Placebo-controlled Single-ascending Dose, First Time Into Man Study to Assess the Safety, Tolerability, and Pharmacokinetics (Part A) and an Open-label Assessment of the Effect of Food on the Pharmacokinetics (Part B) of Orally Administered AZD8418
- collapse A Randomised, Double-blind, Placebo-controlled, Parallel Design, Multicentre Study in Patients With Mild to Moderate Alzheimer's Disease to Investigate the Effect on Cognitive Function as Measured by Repeated CogState Testing in Relation to Effects on Traditional Cognitive Measures After 12 Weeks
- collapse A retrospective, non-interventional study to evaluate the use of Seroquel XR and Seroquel IR in the clinical practice of inpatients with schizophrenia – the SPIN study
- collapse Epidemiological observational non-interventional study to research the prevalence of bipolar criteria of hospital In-patients with schizophrenia and patients with recurrent depression.
